Hydrochloric Acid → HCID 23346248, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 11.2 g of 4-[(4-chlorophenyl)thio]-1,2,3,6-tetrahydropyridine, 10.0 g of 4-chloro-p-fluorobutyrophenone and 6.9 g of potassium carbonate is heated at 98° C. for 1 hour. The mixture is taken up in benzene and filtered. Evaporation of the filtrate gives a brown oil which is treated with a large excess of 1 N hydrochloric acid. The resulting precipitate is collected to afford 8.9 g (46%) of tan powder, m.p. 208°-210° C. Recrystallization from acetonitrile yields off-white crystals, m.p. 220°-222° C.

Provenance & Evidence