Hydrogen Peroxide → HCID 23346242, compound

Participants

Reaction Steps

A solution of 7.5 g of 4-{4-[(4-chlorophenyl)thio]-1,2,3,6-tetrahydro-1-pyridinyl}-1-(4-fluorophenyl)-1-butanone hydrochloride, 1.8 g of 30% hydrogen peroxide in 100 ml of acetic acid is allowed to stand at room temperature for 6 days. A small quantity of sodium bisulfite is added after which the acetic acid is removed in vacuo. The residue is neutralized with dilute sodium carbonate solution, and the product extracted into chloroform. The solvent is evaporated to give an oil. The tartrate salt is generated in ether and triturated with boiling ethyl acetate to yield a white powder, m.p. 159°-160° C.

Provenance & Evidence