HCID 23346099, compound → HCID 23346115, compound

Participants

Reaction Steps

A mixture of 3.0 g. (0.0075 mole) of 1,2-dihydro-8-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-6-methyl-5-nitro-4H-pyrrolo[3,2,1-ij]quinolin-4-one, 150 ml. of alcohol, and 0.5 g. of 10% palladium on charcoal is hydrogenated at an initial pressure of 3 atmospheres in a Parr shaker apparatus until uptake is complete. The catalyst is filtered off, and the filtrate is evaporated. Recrystallization of the residue from alcohol gives 1.7 g (62% ) of 1,2-dihydro-8-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)-ethyl]-5-amino-6-methyl-4H-pyrrolo[3,2,1-ij]quinolin-4-one, m.p. 292°-293°.

Provenance & Evidence