Diketene → HCID 23346106, compound

Participants

Reaction Steps

To a stirred solution of 6.0 g (0.02 mole) of α,α-bis(trifluoromethyl)-2,3-dihydro-2-methyl-1H-indole-5-methanol in 50 ml of anhydrous tetrahydrofuran is added 1.9 g (0.022 mole) of diketene. After 16 hours at room temperature, the solution is refluxed for one hour. The solvent is evaporated, and the residue is recrystallized from dibutyl ether to give 5.7 g (74%) of α,α-bis(trifluoromethyl)-1-(1,3-dioxobutyl)-2,3-dihydro-2-methyl-1H-indole-5-methanol, m.p. 118°-119°.

Provenance & Evidence