HCID 23346088, compound → HCID 23346092, compound

Participants

Reaction Steps

By the method shown in Example 14, α,α-bis(trifluoromethyl)-2,3,4,5-tetrahydro-1H-1-benzazepine-7-methanol is converted to α,α-bis(trifluoromethyl)-1-(1,3-dioxobutyl)-2,3,4,5-tetrahydro-1H-1-benzazepine-7-methanol, m.p. 169°-171°, which is cyclized by heating in sulfuric acid (in this instance at 120° for 24 hours) to give 5,6,7,8-tetrahydro-10-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1-methyl-3H-azepino[3,2,1-ij]quinolin-3-one, m.p. 197°-198°.

Provenance & Evidence