HCID 23346122, compound → HCID 23346123, compound

Participants

Reaction Steps

A mixture of 0.7 g. of 7-chloro-2,3-dihydro-9-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1H,5H-benzo[ij]quinolizin-5-one, 150 ml. of glacial acetic acid, 5 g. of sodium acetate trihydrate, and 0.5 g. of 10% palladium on charcoal is hydrogenated in a Parr shaker apparatus for 4 hours at an initial pressure of 3 atm. The catalyst is removed by filtration, solvent is removed by evaporation, and the residue is triturated with water. The insoluble material is filtered off, dried and recrystallized to give 2,3-dihydro-9-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1H,5H-benzo[ij]quinolizin-5-one, m.p. 295°-296°.

Provenance & Evidence