HCID 20291277, compound → HCID 23346089, compound

Participants

Reaction Steps

By the method of Example 7, α-(difluoromethyl)-α-(trifluoromethyl)-2,3-dihydro-1H-indole-5-methanol is converted to α-(difluoromethyl)-α-(trifluoromethyl)-1-(1,3-dioxobutyl)-2,3-dihydro-1H-indole-5-methanol, m.p. 140°-143°, which is cyclized by heating in sulfuric acid to give 1,2-dihydro-8-[2,2,-difluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-6-methyl-4H-pyrrolo[3,2,1-ij]quinolin-4-one, m.p. 317°-318°.

Provenance & Evidence