HCID 20291279, compound → HCID 23346102, compound

Participants

Reaction Steps

By the method of Example 7, α-(chlorodifluoromethyl)-α-(trifluoromethyl)-2,3-dihydro-1H-indole-5-methanol is converted to α-(chlorodifluoromethyl)-α-trifluoromethyl)-1-(1,3-dioxobutyl)-2,3-dihydro-1H-indole-5-methanol, m.p. 160°-164°, which is cyclized by heating in sulfuric acid to give 1,2-dihydro-8 [2-chloro-2,2-difluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-6-methyl-4H-pyrrolo[3,-2,1-ij]quinolin-4-one, m.p. 294°-295°.

Provenance & Evidence