Carbon Dioxide → HCID 23346417, compound

HRID 1856223Notes

Reaction equation

HRID 1856223 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[C:14]([C:15]([F:18])([F:17])[F:16])=[C:7]2[C:8]([O:10][C:11](=O)[NH:12][C:6]2=[CH:5][CH:4]=1)=[O:9].C[O-].[Na+].C(=O)=O>CO>[F:1][C:2]([F:19])([F:20])[C:3]1[C:14]([C:15]([F:18])([F:16])[F:17])=[C:7]([C:8]([O:10][CH3:11])=[O:9])[C:6]([NH2:12])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 280Carbon DioxideHCID 10942334Sodium MethoxideHCID 53634814HCID 53634814, compound

Product 1

HCID 23346417HCID 23346417, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The anhydride (195 g., 0.65 mol.) is suspended in 750 ml. of dry methanol and treated with sodium methoxide. The mixture is refluxed for 30 minutes until evolution of carbon dioxide stopped. The mixture is cooled, filtered, acidified with acetic acid and evaporated to yield methyl 5,6-bis(trifluoromethyl)anthranilate.

Workup

  1. temperatureThe mixture is cooled
  2. filtrationfiltered
  3. customevaporated

Sources & evidence

ORD record
ord-f8695f5c9011427c92df97d20fb40ab2
Source dataset
uspto-grants-1980_08
Patent number
US04218464

Reaction notes

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