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HRID1856259

反应详情

EQUATION

反应方程式

HRID 1856259 的结构方程式

REACTANTS

反应物

2
结构：Cc1[nH]cnc1CSCCN
HCID665568

4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole

C7H13N3S

结构：CSc1ncc(Cc2ccc(Cl)cc2)c(=O)[nH]1
HCID12945980

未命名化合物

PRODUCTS

生成物

1
结构：Cc1[nH]cnc1CSCCNc1ncc(Cc2ccc(Cl)cc2)c(=O)[nH]1
HCID3047301

4(1H)-Pyrimidinone, 5-((4-chlorophenyl)methyl)-2-((2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)amino)-

C18H20ClN5OS

PROCEDURE

实验过程

An intimate mixture of 5-(4-chlorobenzyl)-2-methylthio-4-pyrimidone (17.7 g) and 2-(5-methyl-4-imidazolylmethylthio)ethylamine (11.4 g) was heated at 145°-150° for 5 hours. After cooling, the reaction mixture was triturated with water to give the free base, which was separated by decantation and recrystallised from methanol to give 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(4-chlorobenzyl)-4-pyrimidone m.p. 204.5°-206°.

WORKUP

后处理

  1. temperaturewas heated at 145°-150° for 5 hours
  2. temperatureAfter cooling
  3. customthe reaction mixture was triturated with water
  4. customto give the free base, which
  5. customwas separated by decantation
  6. customrecrystallised from methanol