Hydrochloric Acid → 2-[2-(3-Bromo-2-pyridylmethylthio)ethylamino]-5-(4-chlorobenzyl)-4-pyrimidone monohydrochloride

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	5-(4-Chlorobenzyl)-2-methylthiopyrimid-4-one	HCID 12945980	—
Reactant	2-{[(3-Bromopyridin-2-yl)methyl]sulfanyl}ethan-1-amine	HCID 12951527	—
Product	2-[2-(3-Bromo-2-pyridylmethylthio)ethylamino]-5-(4-chlorobenzyl)-4-pyrimidone monohydrochloride	HCID 23346179	—

Reaction Steps

5-(4-Chlorobenzyl)-2-methylthio-4-pyrimidone (1.2 g) was reacted with 2-(3-bromo-2-pyridylmethylthio)ethylamine (1.1 g) according to the procedure of Example 2. The reaction mixture was acidified with dilute ethanolic hydrogen chloride, evaporated to dryness and the residue recrystallised from ethanol/water to give 2-[2-(3-bromo-2-pyridylmethylthio)ethylamino]-5-(4-chlorobenzyl)-4-pyrimidone monohydrochloride, m.p. 215°-218° (decomposes).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04218452
Source dataset	uspto-grants-1980_08
ORD ID	ord-b18f9d595f00468bbeb35d39037bffc8
Source note	uspto-grants-1980_08