HCID 23346469, compound → HCID 23346467, compound

HRID 1856275Notes

Reaction equation

HRID 1856275 reaction equation
[C:1]12([CH2:16][CH2:15][CH2:14][CH2:13]1)[C:9]1[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=1)[C:3]([CH:10]([OH:12])[CH3:11])=[CH:2]2>[O-2].[O-2].[Mn+4]>[C:10]([C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[C:1]2([CH2:16][CH2:15][CH2:14][CH2:13]2)[CH:2]=1)(=[O:12])[CH3:11]

Participants

3

Reactant 1

HCID 23346469HCID 23346469, compound

Product 1

HCID 23346467HCID 23346467, compound

Reagents, catalysts & solvents 1

HCID 178418406HCID 178418406, compoundCatalyst

Procedure

The alcohol from step (a) (14.3 g) is stirred for 2 days at about 20° C. with manganese dioxide (150 g) in light petroleum ether (b.p. 40°-60° C.; 450 ml). Solid material is filtered off and the filtrate concentrated. Distillation of the residual oil gives the title ketone, b.p. 148°-150° C./0.5 torr.

Workup

  1. filtrationSolid material is filtered off
  2. concentrationthe filtrate concentrated
  3. distillationDistillation of the residual oil

Sources & evidence

ORD record
ord-166ed40d189a43e5ae4c56229f3890fd
Source dataset
uspto-grants-1980_08
Patent number
US04218472

Reaction notes

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