HCID 23346467, compound → HCID 23346443, compound

Participants

Reaction Steps

Pyrrolidone hydrotribromide [(pyrrolidone)3HBr3 ] is added at about 20° C. to the ketone from step (b) (12 g) in tetrahydrofuran (1500 ml) containing 10 drops of concentrated sulphuric acid. The mixture is stirred for 24 hours. Precipitated salts are removed by filtration and the filtrate is concentrated to a small volume. Water (200 ml) is added and the mixture is extracted three times with diethyl ether. After drying the solvent is evaporated, yielding a semi-crystalline residue. Crystallization from methanol gives the pure bromoacetyl title compound, m.p. 75°-77° C.

Provenance & Evidence