Sulfuric Acid → HCID 23346462, compound

Participants

Reaction Steps

To 3'-bromospiro(cyclopentane-1,1'-indene) (7.5 g) in tetrahydrofuran, (500 ml) is added at -70° C. a solution of n-butyllithium in hexane (200 ml of a 1.8 M solution) in two portions. The temperature is kept at -70° C. for a further 30 minutes. Dimethylformamide (73 g) is then added and the mixture is allowed to come to about 20° C. After 3 hours sulphuric acid (400 ml; 1 M) and diethyl ether (200 ml) are added. The ether phase is separated, washed with saturated sodium chloride solution and dried over sodium sulphate. Evaporation of the ether and distillation gives the title aldehyde; b.p. 130°-135° C./0.1 torr.

Provenance & Evidence