Acetic Acid → HCID 12546902, compound

HRID 1856299Notes

Reaction equation

HRID 1856299 reaction equation
[Br:1][CH2:2][CH2:3][C:4]([NH:6][C:7]1[C:12]([CH3:13])=[CH:11][CH:10]=[CH:9][C:8]=1[CH2:14]C)=[O:5].[CH2:16]([O:19]C1C=C(C)C(=C(C)C=1)N)[CH2:17][CH3:18].C(O)(=O)C.O.O.O.C([O-])(=O)C.[Na+]>O>[Br:1][CH2:2][CH2:3][C:4]([NH:6][C:7]1[C:8]([CH3:14])=[CH:9][C:10]([O:19][CH2:16][CH2:17][CH3:18])=[CH:11][C:12]=1[CH3:13])=[O:5]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 12546817HCID 12546817, compoundHCID 12546900HCID 12546900, compoundHCID 23665404Sodium Acetate Trihydrate

Product 1

HCID 12546902HCID 12546902, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

This compound was prepared analogously to 3-bromo-2'-ethyl-6'-methylpropionanilide of Example 11A from 20 g 4-propoxy-2, 6-xylidine, 95 ml glacial acetic acid, 37 g sodium acetate trihydrate, 150 ml water 21.2 g 3-bromopropionyl bromide. The yield was 93% of recrystallized (methanol:water) material melting at 121.5°-122.5° C.

Workup

  1. customThe yield was 93% of recrystallized (methanol:water) material melting at 121.5°-122.5° C.

Sources & evidence

ORD record
ord-e2c904061226497ea41f68e2a52d6c63
Source dataset
uspto-grants-1980_08
Patent number
US04218477

Reaction notes

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