HCID 12546902, compound → Phthalimide

Participants

Reaction Steps

This compound was prepared analogously to 3-amino-2'-ethyl-6'-methylpropionanilide of Example 11B from 15.7 g 3-bromo-2',6'-dimethyl-4'-propoxypropionanilide and 10.2 g potassium phthalimide in 50 ml dimethyl formamide. The intermediate phthalimide derivative was obtained in 88% yield. It was decomposed by being suspended in 250 ml 95% alcohol with addition of 4 ml of 64% hydrazine and refluxing for 90 min. A hydrochloride was prepared from the obtained base; m.p. 208°-210.5° C. Calcd. for C14H23ClN2O2 : C 58.6, H 8.08, Cl 12.4, N 9.77. Found: C 58.8, H 8.20, Cl 12.3, N 9.96.

Provenance & Evidence