Benzene → HCID 20070653, compound

Participants

Reaction Steps

The o-nitrobenzylglyoxylate, from Step B, is dissolved in 100 ml of benzene and refluxed using a Dean-Stark water separator containing 5 g of CaH2 for 0.5 hr; trans-3-[o-nitrobenzyloxycarbonylamino]-4-[2-acetoxyethyl]-2-azetidinone (3.51 g) is added and the mixture is refluxed for 6 hours, cooled and evaporated. The residue is chromatographed to give trans-1-(o-nitrobenzyloxycarbonylhydroxymethyl)-3-(o-nitrobenzyloxycarbonylamino)-4-(2-acetoxyethyl-2-azetidinone (3.8 g).

Provenance & Evidence