HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-2-[2-(2-nitrophenyl)diazenyl]phenol → Drometrizole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-2-[2-(2-nitrophenyl)diazenyl]phenol | HCID 74029 | — |
| Reactant | 2-Nitro-2'-hydroxy-3',5'-bis(tert-amyl)azobenzene | HCID 104111 | — |
| Catalyst | Nickel | HCID 935 | — |
| Catalyst | Molybdenum | HCID 23932 | — |
| Product | Drometrizole | HCID 17113 | 60.3% |
Reaction Steps
When using the procedure of Example 1, the 2-nitro-2'-hydroxy-3',5'-di-tert-amylazobenzene was replaced by an equivalent amount of 2-nitro-2'-hydroxy-5'-methylazobenzene and a total of 9% molybdenum-promoted Raney nickel catalyst was used, the above named compound was obtained in a 60.3% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04219480 |
| Source dataset | uspto-grants-1980_08 |
| ORD ID | ord-43681fd27c324be7b781edbe725e0938 |
| Source note | uspto-grants-1980_08 |