HCID 86735504, compound → HCID 86735503, compound

HRID 1856448Notes

Reaction equation

HRID 1856448 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:16]([F:19])([F:18])[F:17])[CH:7]=[CH:6][C:5]=1[O:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[C:33]([F:36])([F:35])[F:34])=[CH:23][C:22]=1[N+:37]([O-])=O)([O-])=O.[H][H]>C(O)C.[Pt]=O>[NH2:37][C:22]1[CH:23]=[C:24]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[C:33]([F:35])([F:36])[F:34])[CH:25]=[CH:26][C:21]=1[O:20][C:5]1[CH:6]=[CH:7][C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:16]([F:17])([F:18])[F:19])=[CH:9][C:4]=1[NH2:1]

Participants

5

Reactant 2

HCID 86735504HCID 86735504, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 86735503HCID 86735503, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

2-Nitro-α,α,α-trifluoro-p-tolylphenyl ether (57.0 g., 0.209 mole) is dissolved in ethanol (200 ml.) and shaken in an atmosphere of hydrogen in a Parr apparatus in the presence of platinum oxide (100 mg.) until uptake is complete. The catalyst is removed by filtration and the solvent stripped off to give 2-amino-α,α,α-trifluoro-p-tolyl phenylether (50.3 g. 99%) which is used without further purification.

Workup

  1. customThe catalyst is removed by filtration

Sources & evidence

ORD record
ord-cc32073fc8be496684393bc825fc8a4f
Source dataset
uspto-grants-1980_08
Patent number
US04219352

Reaction notes

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