HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 1-Phenylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | HCID 23345028 | HCID 23345028 | — |
| Solvent | Chloroform methanol | HCID 21584188 | — |
| Product | 1-Phenylpiperazine | HCID 7096 | 95% |
| Product | HCID 23345045 | HCID 23345045 | — |
Reaction Steps
From 8.6 mmol of 4-[3-(2,3 -epoxypropoxy)phenyl]-2-pyrrolidone and 8.6 mmol of 1-phenylpiperazine (95% strength), 4-{3-[2-hydroxy-3-(4-phenylpiperazin-1-yl)propoxy]phenyl}-2-pyrrolidone, m.p. 82°-84°, is obtained analogously to Example 1 in a 77% yield (ether; after chromatography in methanol/chloroform 2:8).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04219551 |
| Source dataset | uspto-grants-1980_08 |
| ORD ID | ord-593cab39ad5f40fdbbfd477bfd0d3894 |
| Source note | uspto-grants-1980_08 |