反应详情

7.5 mmol of 4-{4-methoxy- 3-[3-(4-phenylpiperazin-1-yl)-2-hydroxypropoxy]phenyl}-2-pyrrolidone is dissolved in 50 ml. of dry pyridine. After adding 15 mmol of acetic anhydride, the mixture is heated for 3 hours under reflux. After cooling, the reaction mixture is concentrated under vacuum. The residue is chromatographed over silica gel (acetone/dichloromethane 1:1) and recrystallized from isopropanol, thus obtaining in an 86% yield 4-{4-methoxy-3-[3-(4-phenylpiperazin-1-yl)-2-acetoxypropoxy]phenyl}-2-pyrrolidone, m.p. 128°-133°.

1. temperaturethe mixture is heated for 3 hours
2. temperatureunder reflux
3. temperatureAfter cooling
4. concentrationthe reaction mixture is concentrated under vacuum
5. customThe residue is chromatographed over silica gel (acetone/dichloromethane 1:1)
6. customrecrystallized from isopropanol