Water → CH 150

HRID 1856477Notes

Reaction equation

HRID 1856477 reaction equation
Cl.[CH3:2][C:3]1[N:4]=[C:5]2[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[N:6]2[C:7](=[O:11])[C:8]=1[CH2:9][CH3:10].O.C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)(Cl)Cl>[CH3:2][C:3]1[N:4]=[C:5]2[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[N:6]2[C:7](=[O:11])[C:8]=1[CH2:9][CH3:10]

Participants

5

Reactant 3

HCID 962WaterHCID 10340Sodium CarbonateHCID 1553734H-Pyrido(1,2-a)pyrimidin-4-one, 2,6-dimethyl-3-ethyl-, monohydrochloride

Product 1

HCID 93406CH 150Yield 99%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

4.77 g. of 2,6-dimethyl-3-ethyl-4-oxo-4H-pyrido[1,2-a]pyrimidine hydrochloride are dissolved in 50 ml. of water and the pH-value of the mixture is adjusted to 7 with a 10% aqueous sodium carbonate solution. The reaction mixture is shaken with four 25-ml. portions of chloroform, the chloroform extracts are combined, dried over sodium sulphate and evaporated. Ethyl acetate is distilled through the residue. 4.0 g. (99%) of 2,6-dimethyl-3-ethyl-4-oxo-4H-pyrido[1,2-a]pyrimidine are obtained, melting at 127° to 128° C. after recrystallization from a mixture of ethanol and ether.

Workup

  1. dry with materialdried over sodium sulphate
  2. customevaporated
  3. distillationEthyl acetate is distilled through the residue

Sources & evidence

ORD record
ord-5fc88d5de47248eeb03c093582257c19
Source dataset
uspto-grants-1980_08
Patent number
US04219649

Reaction notes

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