Hydrochloric Acid → 4H-Pyrido(1,2-a)pyrimidin-4-one, 7-chloro-3-ethyl-2-methyl-, monohydrochloride

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Reaction Steps

4.45 g. of 2-methyl-3-ethyl-7-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidine are dissolved in ethanol, with heating, then 25 ml. of a 28% by weight solution of hydrogen chloride in ethanol is added to the solution obtained. Upon the precipitated crystals are filtered off and washed with ethanol. 5.01 g. (97%) of 2-methyl-3-ethyl-7-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidine hydrochloride are obtained, m.p.=176° to 180° C.

Provenance & Evidence