Aniline → HCID 23345442, compound

Participants

Reaction Steps

A 4.50 g. portion of 5-chloro-4-ethoxy-3-thiophenecarbonyl chloride (prepared as in Example 4) was dissolved in 40 ml. of methylene chloride and stirred overnight with 2.8 ml. of triethylamine and 1.86 g. of aniline. The mixture was filtered and the filtrate extracted with 3 N hydrochloric acid. The methylene chloride layer was treated with activated charcoal, dried over anhydrous sodium sulfate and diluted with petroleum ether to give 3.62 g. of the product of the example as a white crystalline solid, m.p. 69° C.

Provenance & Evidence