反应详情

58 G. of 4-chlorothiophenol and a solution of 26.5 g. of 85% potassium hydroxide in 1500 ml. of ethanol were each placed in a 3 l. three-necked flask, provided with a condenser, nitrogen inlet, dropping funnel and stirrer. The solution was brought to reflux and a solution of 105 g. of crude 3-bromo-4-oxocyclohexaneacetic acid ethyl ester in 500 ml. of ethanol was added over a period of one hour to the refluxing solution. After the addition, the solution was stirred at reflux for one hour, cooled to room temperature, and filtered to remove the potassium bromide. After removal of the ethanol in vacuo (steam bath, rotary evaporator), 300 ml. of water was added to the residue, the product was extracted three times with 200 ml. of ether and the ether extract dried over anhydrous magnesium sulfate. After removal of ether from a steam bath at atmospheric pressure, the residue, weighing 128 g., was distilled in vacuo. A forerun weighing 28.7 g. was collected at 100°-190° (1 mm.), while 76.4 g. of a main fraction collected at 190°-222° (1 mm.). A gas chromatographic determination of the main fraction showed that 3-(4-chlorophenylthio)-4-oxocyclohexaneacetic acid ethyl ester was present.

1. customthree-necked flask, provided with a condenser, nitrogen inlet
2. temperatureto reflux
3. additionAfter the addition
4. temperatureat reflux for one hour
5. filtrationfiltered
6. customto remove the potassium bromide
7. customAfter removal of the ethanol
8. customin vacuo (steam bath, rotary evaporator), 300 ml
9. additionof water was added to the residue
10. extractionthe product was extracted three times with 200 ml
11. extractionof ether and the ether extract
12. dry with materialdried over anhydrous magnesium sulfate
13. customAfter removal of ether from a steam bath at atmospheric pressure
14. distillation, was distilled in vacuo
15. customwas collected at 100°-190° (1 mm.)
16. customof a main fraction collected at 190°-222° (1 mm.)