HCID 12891626, compound → HCID 88784466, compound

Participants

Reaction Steps

A mixture of 7.5 parts of 1-(4-fluorophenylmethyl)-N-[1-{2-[4-(phenylmethoxy)phenyl]ethyl}-4-piperidinyl]-1H-benzimidazol-2-amine and 120 parts of methanol is hydrogenated at normal pressure and at room temperature with 2 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen is taken up, the catalyst is filtered off and the filtrate is evaporated. The residue is suspended in 2,2'-oxybispropane. The product is filtered off and dried, yielding 5.5 parts (88.5%) of 4-[2-{4-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-ylamino]-1-piperidinyl}ethyl]phenol hemihydrate; mp. 111.6° C.

Provenance & Evidence