Hydrochloric Acid → HCID 22131683, compound

Participants

Reaction Steps

A mixture of 4'-(4-methoxymethylcyclohexyl)-4-trifluoromethoxybiphenyl (100 mmol), TMSI (144 mmol), 15 ml of acetonitrile, and 10 ml of methylene chloride was stirred at room temperature for 4 hr. Ice and 6 M HCl were added to the reaction mixture, and the mixture was stirred. The organic phase was washed twice with a saturated aqueous solution of sodium thiosulfate. It was then dried over magnesium sulfate anhydride, and the solvent was distilled off under reduced pressure to give a crude product. The crude product was purified by silica gel column chromatography (eluting solution: toluene--(1:1) mixture of toluene and ethyl acetate) to give 4'-(4-hydroxymethylcyclohexyl)-4-trifluoromethoxybiphenyl (68 mmol, yield 68%).

Provenance & Evidence