Acetone → 4-Benzyl-1,4,7,10-tetraazacyclododecane-2,6-dione

HRID 1856604Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1856604
C[CH:2]([N:6]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH:7](C)[C:8]([O-:10])=O)[C:3]([O-:5])=O.[NH2:19][CH2:20][CH2:21][NH:22][CH2:23][CH2:24][NH2:25].CC(C)=O>C(O)C>[CH2:12]([N:6]1[CH2:2][C:3](=[O:5])[NH:25][CH2:24][CH2:23][NH:22][CH2:21][CH2:20][NH:19][C:8](=[O:10])[CH2:7]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Komponenten

5

Edukt 3

HCID 180AcetoneHCID 8111DiethylenetriamineHCID 131719217dimethyl-N-benzyl-iminodiacetate

Produkt 1

HCID 157028294-Benzyl-1,4,7,10-tetraazacyclododecane-2,6-dioneAusbeute 14,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

To a solution of 31.2 g dimethyl-N-benzyl-iminodiacetate in 2.5 l of dry ethanol at reflux under nitrogen was added dropwise 12.8 g of diethylenetriamine in 160 ml of dry ethanol. Reflux was carried out for a total of 137 hours. The solution was evaporated under reduced pressure leaving a yellow paste. Trituration with acetone left 5.2 g of the desired product as a colorless solid.

Aufarbeitung

  1. temperatureReflux
  2. customwas carried out for a total of 137 hours
  3. customThe solution was evaporated under reduced pressure
  4. customleaving a yellow paste

Quellen und Nachweise

ORD-Eintrag
ord-a14cf4a09a3146ce976b2ef6a8ec89b5
Quelldatensatz
uspto-grants-2000_11
Patentnummer
US06143274

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