反应详情

17.5 g (0.05 mole) of N-[2-hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarbox-imidamide dihydrochloride was dissolved in 50 ml of thionyl chloride, boiled for one hour, then the mixture was evaporated to dryness. The residue was dissolved in 300 ml of methanol, treated with charcoal and after filtration the solvent was evaporated in reduced pressure. The residue was dissolved in the minimum amount of ethanol and refrigerated to yield crystalline N-[2-chloro-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide dihydrochloride as intermediate compound.

1. customthe mixture was evaporated to dryness
2. dissolutionThe residue was dissolved in 300 ml of methanol
3. additiontreated with charcoal
4. filtrationafter filtration the solvent
5. customwas evaporated in reduced pressure
6. dissolutionThe residue was dissolved in the minimum amount of ethanol