Sodium Hydroxide → HCID 20637915, compound

Participants

Reaction Steps

To a solution of Example 75 (1.5 g) in methanol (100 mL) was added SnCl2 ·H2O (3.06) and the resulting mixture was heated at reflux for 8 hours. The mixture was cooled to ambient temperature, poured into ice and was adjusted to pH5 with 1N NaOH. The methanol was evaporated off and the residue was basified to pH11 with 1N NaOH and extracted with EtOAc (2×150 mL). After drying over Na2SO4 and evaporation of EtOAc, the resulting yellow powder was purified by radial chromatography eluting with CH2Cl2 to give the title compound as a white powder (550 mg) m.p.: 192° C.

Provenance & Evidence