HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Benzyl (piperidin-4-ylmethyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1-N-Boc-4-(N-cbz-aminomethyl)piperidine | HCID 11792026 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Benzyl (piperidin-4-ylmethyl)carbamate | HCID 14809798 | — |
Reaction Steps
To a solution of 3 (4.4 g, 13 mmol) in 90 ml of methylene chloride was added 45 ml of TFA. After stirring at room temperature for 24 hours, the solvents were removed in vacuo and the residue partitioned between chloroform and 10% Na2CO3. The organics were dried over MgSO4, filtered, and the solvent removed in vacuo to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06143750 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-1ecc78736c924f2aa223408fd5cf7d54 |
| Source note | uspto-grants-2000_11 |