Benzyl isocyanate → HCID 69791284, compound

HRID 1856664Notes

Reaction equation

HRID 1856664 reaction equation
[C:1]1([C@H:7]2[C:12]3[NH:13][C:14]4[C:19]([C:11]=3[CH2:10][C@H:9]([C:20](OC)=[O:21])[NH:8]2)=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:24]([N:31]=[C:32]=[O:33])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[CH2:24]([N:31]1[C:20](=[O:21])[C@H:9]2[N:8]([C@@H:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[C:12]3[NH:13][C:14]4[CH:15]=[CH:16][CH:17]=[CH:18][C:19]=4[C:11]=3[CH2:10]2)[C:32]1=[O:33])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 76639Benzyl isocyanateHCID 736465HCID 736465, compound

Product 1

HCID 69791284HCID 69791284, compound

Procedure

The same method as employed in the preparation of Example 1 but starting from trans methyl 1,2,3,4-tetrahydro-1-phenyl-9H-pyrido[3,4-b]indole-3-carboxylate (see J. Cook et al., Heterocycles, 4(7), 1249-1255 (1976)) and benzyl isocyanate gave after recrystallization from diethyl ether, the title compound as white crystals m.p.: 200-202° C.

Workup

  1. customThe same method as employed in the preparation of Example 1
  2. customgave
  3. customafter recrystallization from diethyl ether

Sources & evidence

ORD record
ord-83708b240c6d4799a148931b9ec41743
Source dataset
uspto-grants-2000_11
Patent number
US06143757

Reaction notes

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