Sodium Carbonate → HCID 53829171, compound

Participants

Reaction Conditions

Reaction Steps

Prepared according to the method described in Example 21b) from (1S,2R)-4-(2-hydroxy-1-methyl-4-pyridin-3-ylbutoxy)benzeneboronic acid (0.150 g, Example 21a), 4-iodo-2-methoxypyridine (0.235 g, Liebigs Annalen der Chemie (1992) Issue 9, 953-9), ethanol (3 ml), 2M aqueous sodium carbonate (0.5 ml) and tetrakis(triphenylphosphine)palladium(0) (0.025 g) with heating at 90° C. for 4 hours. After work up, the residue was purified by normal-phase HPLC, eluting with a gradient of 0-25% ethanol in dichloromethane to give the title compound as an oil (0.069 g).

Provenance & Evidence