Sodium Carbonate → HCID 54530686, compound

Participants

Reaction Conditions

Reaction Steps

Prepared according to the method described in Example 21b) from (2R)-4-(2-hydroxy-4-pyridin-3-ylbutoxy)benzeneboronic acid (0.15 g, Example 28a)), 5-bromopyridine-3-carbonitrile (0.19 g), 2M aqueous sodium carbonate (0.60 ml) and tetrakis(triphenylphosphine)palladium(0) (0.014 g) with heating at 90° C. for 4 hours. After work up, the residue was purified by normal-phase HPLC eluting with a gradient of 0-10% ethanol in dichloromethane to give the title compound as an oil (0.10 g).

Provenance & Evidence