Cyclohexene oxide → (1R,2R)-2-(Cyclopropylamino)cyclohexan-1-ol

Participants

Reaction Steps

Cyclohexene oxide (143 ml) and cyclopropylamine (82 g) are dissolved in methanol (1 liter), and the mixture is refluxed for 5 hours. The mixture is concentrated under reduced pressure to remove the solvent, and the resulting residue is distilled under reduced pressure to give trans-N-(2-hydroxycyclohexyl)-N-cyclopropylamine (126 g) as a colorless oil.

Provenance & Evidence