Hydrazine → HCID 22132608, compound

Participants

Reaction Steps

To a suspension of 2-chloro-6-(3-phthalimidopropoxy)quinoline (9.0 g) in ethanol (250 ml) is added hydrazine.monohydrate (1.4 g), and the mixture is refluxed for 7.5 hours. The mixture is allowed to cool, and the precipitated crystals are collected by filtration, and suspended in water. The mixture is acidified with conc. hydrochloric acid, and stirred for one hour. The mixture is basified with a 10% aqueous potassium hydroxide solution, and extracted with chloroform. The extract is dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent to give 2-chloro-6-(3-aminopropoxy)quinoline (4.7 g) as a white powder.

Provenance & Evidence