HCID 22132535, compound → HCID 22132520, compound

Participants

Reaction Steps

A mixture of 7-bromo-2-methoxycarbonyl-1,2,3,4-tetrahydroisoquinoline (12.0 g, 0.044 mol), copper (I) cyanide (8.7 g, 0.097 mol) and N-methyl-2-pyrrolidinone (100 ml) was heated at reflux for 4 h, cooled, then partitioned between dilute aqueous ammonia (500 ml) and ethyl acetate (300 ml). Organic phase was washed with dilute aqueous ammonia (100 ml), water (4×100 ml), then dried (Na2SO4) and evaporated in vacuo to give the title compound as an oil (7.89 g, 83%).

Provenance & Evidence