HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(benzo[1,3]dioxol-5-ylmethyl)-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide → Methyl 4-{3-[(benzo[1,3]dioxol-5-ylmethyl)carbamoyl]-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylcarbamoyl}cyclohexanecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(benzo[1,3]dioxol-5-ylmethyl)-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide | HCID 11782481 | — |
| Reactant | Methyl 4-(chlorocarbonyl)cyclohexane-1-carboxylate | HCID 15380636 | — |
| Product | Methyl 4-{3-[(benzo[1,3]dioxol-5-ylmethyl)carbamoyl]-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylcarbamoyl}cyclohexanecarboxylate | HCID 15380637 | — |
Reaction Steps
Analogously to Example 1, the reaction of N-(benzo[1,3]dioxol-5-ylmethyl)-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide with 4-methoxycarbonylcyclohexanecarbonyl chloride ("B") gives the compound methyl 4-{3-[(benzo[1,3]dioxol-5-ylmethyl)carbamoyl]-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylcarbamoyl}cyclohexanecarboxylate, m.p. 173°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06143777 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-245f597757d0494b944fa386756496b4 |
| Source note | uspto-grants-2000_11 |