HCID 13747407, compound → HCID 13747409, compound

HRID 1857001Notes

Reaction equation

HRID 1857001 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([CH2:10][C:11]([NH:13][CH:14]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[N:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[CH2:15][CH2:16][CH3:17])=[O:12])[CH:7]=[CH:6][C:5]=1[CH2:30][CH2:31][C:32]([O:34]CC)=[O:33])[CH3:2]>C(Cl)(Cl)Cl.CO>[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([CH2:10][C:11]([NH:13][CH:14]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[N:24]2[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]2)[CH2:15][CH2:16][CH3:17])=[O:12])[CH:7]=[CH:6][C:5]=1[CH2:30][CH2:31][C:32]([OH:34])=[O:33])[CH3:2]

Participants

3

Reactant 1

HCID 13747407HCID 13747407, compound

Product 1

HCID 13747409HCID 13747409, compound

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

Prepared analogously to Example 5 by alkaline saponification of ethyl 3-[2-ethoxy-4-[N-(1-(2-piperidino-phenyl)-1-butyl)-aminocarbonylmethyl]-phenyl]-propionate and subsequent purification by column chromatography (chloroform/methanol=9/1).

Sources & evidence

ORD record
ord-93c429bdba6d46548a31e1ae67b9a1e7
Source dataset
uspto-grants-2000_11
Patent number
US06143769

Reaction notes

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