Vinyl propanoate → HCID 14528583, compound

Racemic 1-dimethylamino-2-propanol (100 g, 0.97 mol) was stirred with vinyl propionate (106 ml, 0.97 mol) at ambient temperature and Novozym 435 (6 g) was added. The reaction mixture was stirred slowly for 70 hours and after this time tlc (10% methanol/dichloromethane--visualise KMnO4 solution) indicated that the reaction had gone to 50% conversion. The enzyme was removed by filtration and the filter bed was washed with ethyl acetate (2×100 ml). The organic layer was then washed with water (4×100 ml) and the combined washes were back extracted with ethyl acetate (400 ml). The organic layer was then washed with brine (200 ml) and dried (MgSO4). The ethyl acetate was removed in vacuo to leave 58.7 g (0.37 mol, 70% based on maximum yield of 84.5 g) of (-)-1-dimethylamino-2-propyl propanoate as a yellow oil. δH (220 MHz; CDCl3) 1.13 (3H, t, 7 Hz, CH3CH2CO), 1.21 (3H, d, 6 Hz, H-3), 2.25 (6H, s, N(CH3)2),2.10-2.60 (4H, m, H-1 & CH3CH2CO), 5.09 (1H, m, H-2). The optical purity was not measured at this stage.

1. customThe enzyme was removed by filtration
2. washthe filter bed was washed with ethyl acetate (2×100 ml)
3. washThe organic layer was then washed with water (4×100 ml)
4. extractionthe combined washes were back extracted with ethyl acetate (400 ml)
5. washThe organic layer was then washed with brine (200 ml)
6. dry with materialdried (MgSO4)
7. customThe ethyl acetate was removed in vacuo

ORD record

ord-efd619f552f24b2793b34e7fc003ac71

Source dataset

uspto-grants-2000_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06143933