HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexanecarboxylic acid → HCID 22132668, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexanecarboxylic acid | HCID 7413 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline | HCID 11594543 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 22132668 | HCID 22132668 | 64% |
Reaction Steps
6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (52 mg) and commercially available cyclohexanecarboxylic acid (46 mg) were dissolved in N,N-dimethylformamide (2 ml), 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrochloride (84 mg) was added, and the admixture was stirred at room temperature for 22 hours. The reaction mixture was then purified in the same manner as described in Example 51 to obtain 45 mg of the title compound (yield: 64%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06143764 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-8dc3573be27a4fba9e8a1473ace88f4d |
| Source note | uspto-grants-2000_11 |