HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 22132720, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 4-(Dimethylamino)benzoic acid | HCID 12092 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline | HCID 11594543 | — |
| Product | HCID 22132720 | HCID 22132720 | 10% |
Reaction Steps
6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (51 mg) and commercially available 4-(dimethylamino)benzoic acid (44 mg) were dissolved in N,N-dimethylformamide (2 ml), 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrochloride (83 mg) was added, and the admixture was stirred at room temperature for 16 hours. The reaction mixture was then purified in the same manner as described in Example 51 to obtain 7 mg of the title compound (yield: 10%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06143764 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-1e70c2e1cf304a169516740731b6e084 |
| Source note | uspto-grants-2000_11 |