4-Butoxybenzoyl chloride → 4-Butoxy-N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}benzamide

Participants

Reaction Steps

6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (52 mg) was suspended in triethylamine/methylene chloride (3 ml/2 ml), commercially available 4-butoxybenzoyl chloride (0.07 ml) was added, and the admixture was stirred at room temperature for 30 hours. The reaction mixture was then purified in the same manner as described in Example 62 to obtain 34 mg of the title compound (yield: 41%).

Provenance & Evidence