4-Bromobenzoic acid → 4-Bromo-N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}benzamide

Participants

Reaction Steps

6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (52 mg) and commercially available 4-bromobenzoic acid (78 mg) were dissolved in N,N-dimethylformamide (2 ml), 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrochloride (102 mg) was added, and the admixture was stirred at room temperature for 17 hours. The reaction mixture was then purified in the same manner as described in Example 51 to obtain 43 mg of the title compound (yield: 52%).

Provenance & Evidence