HuagongsheHuagongshe Chemistry Print Report · For research reference only
Picolinic acid → HCID 22132669, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Picolinic acid | HCID 1018 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline | HCID 11594543 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 22132669 | HCID 22132669 | 56.1% |
Reaction Steps
6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (50 mg) and commercially available picolinic acid (42 mg) were dissolved in N,N-dimethylformamide (2 ml), 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrochloride (123 mg) was added, and the admixture was stirred at room temperature for 19 hours. The reaction mixture was then purified in the same manner as described in Example 51 to obtain 38 mg of the title compound (yield: 56%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06143764 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-d3b8417e067548e78f1cde1fdc2bbdb3 |
| Source note | uspto-grants-2000_11 |