Potassium Hydroxide → N-{4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl}-(4-hydroxycarbonylphenyl)carboxamide

Participants

Reaction Steps

{4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl}-(4-methoxycarbonylphenyl)carboxamide was dissolved in methanol (3 ml), 33% aqueous potassium hydroxide (1.5 ml) was added, and the admixture was stirred at room temperature for 2 hours. The reaction mixture was washed 2 times with ethyl acetate, and the water layer was neutralized with dilute hydrocholoric acid and extracted 2 times with chloroform. The chloroform layer was dried with sodium sulfate, and the solvent was then removed by reduced-pressure distillation to obtain 34 mg of the title compound (yield: 45%).

Provenance & Evidence