Potassium Hydroxide → HCID 22132713, compound

Participants

Reaction Steps

N-{4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl}-(4-acetoxyphenyl)carboxamide (103 mg) was dissolved in methanol (4 ml), 35% aqueous potassium hydroxide (2 ml) was added, and the admixture was stirred at room temperature for 5 hours. The reaction mixture was partitioned with ethyl acetate/water, and the ethyl acetate layer was washed with brine and then dried with anhydrous sodium sulfate. The solvent was removed by reduced-pressure distillation, and the resulting crystals were washed with ether to obtain 77 mg of the title compound (yield: 82%).

Provenance & Evidence