Benzene, 1-isocyanato-4-nitro- → HCID 11167070, compound

HRID 1857160Notes

Reaction equation

HRID 1857160 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=1.[N+:23]([C:26]1[CH:31]=[CH:30][C:29]([N:32]=[C:33]=[O:34])=[CH:28][CH:27]=1)([O-:25])=[O:24]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:17]=[CH:18][C:19]([NH:22][C:33]([NH:32][C:29]2[CH:28]=[CH:27][C:26]([N+:23]([O-:25])=[O:24])=[CH:31][CH:30]=2)=[O:34])=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 66012Benzene, 1-isocyanato-4-nitro-HCID 115945434-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline

Product 1

HCID 11167070HCID 11167070, compoundYield 88.1%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (103 mg) was dissolved in toluene (10 ml) with heat, 4-nitrophenyl isocyanate (366 mg) was added, and the admixture was refluxed with heat for 60 minutes. The separated crystals were filtered and washed with toluene to obtain 141 mg of the title compound (yield: 88%).

Workup

  1. temperaturewith heat
  2. temperaturethe admixture was refluxed
  3. temperaturewith heat for 60 minutes
  4. filtrationThe separated crystals were filtered
  5. washwashed with toluene

Sources & evidence

ORD record
ord-2b34131cd2b04908b2e93f4f6f9e6b0d
Source dataset
uspto-grants-2000_11
Patent number
US06143764

Reaction notes

Loading…