反应详情

6,7-Dimethoxy-4-(2-aminophenoxy)quinoline (56 mg), which was obtained, analogously to Example 49, by reducing 6,7-dimethoxy-4-(2-nitrophenoxy)quinoline obtained in the same manner as described in Example 48, except that 2-nitrophenol was used in place of 4-nitrophenol, was dissolved in toluene (3 ml) with heat, 4-n-butylphenyl isocyanate (0.2 ml) was added, and the admixture was refluxed with heat for 30 minutes. The resulting residue was purified by chromatography on silica gel eluting with chloroform/acetone (10/1) to obtain 45 mg of the title compound (yield: 50%).

1. customobtained in the same manner
2. temperaturewith heat
3. temperaturethe admixture was refluxed
4. temperaturewith heat for 30 minutes
5. customThe resulting residue was purified by chromatography on silica gel eluting with chloroform/acetone (10/1)