Butyl isocyanate → HCID 59783956, compound

HRID 1857168Notes

Reaction equation

HRID 1857168 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=1.[CH2:23]([N:27]=[C:28]=[O:29])[CH2:24][CH2:25][CH3:26]>C1(C)C=CC=CC=1>[CH2:23]([NH:27][C:28]([NH:22][C:19]1[CH:18]=[CH:17][C:16]([O:15][C:6]2[C:5]3[C:10](=[CH:11][C:12]([O:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=3)[N:9]=[CH:8][CH:7]=2)=[CH:21][CH:20]=1)=[O:29])[CH2:24][CH2:25][CH3:26]

Participants

4

Reactant 2

HCID 8110Butyl isocyanateHCID 115945434-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline

Product 1

HCID 59783956HCID 59783956, compoundYield 46%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (51 mg) was dissolved in toluene (3 ml) with heat, n-butyl isocyanate (0.2 ml) was added, and the admixture was refluxed with heat for 14 hours. The resulting residue was purified by chromatography on silica gel eluting with chloroform/acetone (10/1) to obtain 31 mg of the title compound (yield: 46%).

Workup

  1. temperaturewith heat
  2. temperaturethe admixture was refluxed
  3. temperaturewith heat for 14 hours
  4. customThe resulting residue was purified by chromatography on silica gel eluting with chloroform/acetone (10/1)

Sources & evidence

ORD record
ord-4b0342bec1fa422ab4352c03a16e44d2
Source dataset
uspto-grants-2000_11
Patent number
US06143764

Reaction notes

Loading…